This roundtable will focus on data and personalization in healthcare, a foundational element of modern medical care delivery. Meaningful personalization depends not only on advanced analytics and AI capabilities, but critically on the availability of high-quality, interoperable and longitudinal data supported by governance frameworks. Despite rapid technological progress, real-world implementation remains challenging. Regulatory constraints, fragmented data infrastructure, limited interoperability and difficulties integrating personalized insights into everyday clinical workflows continue to impede impact at scale. The discussion will explore how cross-sector collaboration between healthcare systems, industry, academia and policymakers is essential to translating personalization into measurable clinical benefit.